Gastro LBM - Laboratório de Biologia Molecular para pesquisa em doenças do Fígado e Aparelho Digestivo
Linhas de pesquisa com interface com a REFARGEN
- Hepatites crônicas virais (pesquisa básica e clínica)
- Cirrose e suas complicações
- Metabolismo de drogas e polimorfismos genéticos
Publicações selecionadas
1. Ono-Nita SK, Kato N, Shiratori Y, Lan KH, Yoshida H, Carrilho FJ, et al. Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors. J Clin Invest. 1999;103(12):1635-40.
2. Ono-Nita S, Kato N, Shiratori Y, Masaki T, Lan K, Carrilho F, et al. YMDD motif in hepatitis B virus DNA polymerase influences on replication and lamivudine resistance: A study by in vitro full-length viral DNA transfection. Hepatology. 1999;29(3):939-45.
3. Kioko Ono-Nita S, Kato N, Shiratori Y, Omata M. Current Options for the Therapy of Chronic Hepatitis B Infection. Curr Infect Dis Rep. 2001;3(2):137-42.
4. Ono SK, Kato N, Shiratori Y, Kato J, Goto T, Schinazi RF, et al. The polymerase L528M mutation cooperates with nucleotide binding-site mutations, increasing hepatitis B virus replication and drug resistance. J Clin Invest. 2001;107(4):449-55.
5. Ono-Nita SK, Kato N, Shiratori Y, Carrilho FJ, Omata M. Novel nucleoside analogue MCC-478 (LY582563) is effective against wild-type or lamivudine-resistant hepatitis B virus. Antimicrob Agents Chemother. 2002;46(8):2602-5.
6. da Costa MZ, Guarita DR, Ono-Nita SK, Nogueira JeA, Nita ME, Paranaguá-Vezozzo DC, et al. CFTR polymorphisms in patients with alcoholic chronic pancreatitis. Pancreatology. 2009;9(1-2):173-81.
7. Astolfi RH, Bugano DD, Francisco AA, de Souza MM, Ono-Nita SK, Baracat EC. Is Gilbert syndrome a new risk factor for breast cancer? Med Hypotheses. 2011;77(2):162-4.
8. Nakatani SM, Santos CA, Riediger IN, Krieger MA, Duarte CA, Lacerda MA, Biondo AW, Carrilho FJ, Ono-Nita SK. Development of hepatitis C virus genotyping by real-time PCR based on the NS5B region. PLoS One. 2010;5(4):e10150.
9. Ferreira Cda S, Abreu RM, da Silva MC, Ferreira AS, Nasser PD, Carrilho FJ, Ono SK. A fast and cost-effective method for identifying a polymorphism of interleukin 28B related to hepatitis C. PLoS One. 2013;8(10):e78142.
10. Kim V, Abreu RM, Nakagawa DM, Baldassare RM, Carrilho FJ, Ono SK. Pegylated interferon alfa for chronic hepatites B: systematic review and meta-analysis. J Viral Hepatitis. 2015
Líder(es) do grupo:
Suzane Kioko Ono
Lattes: 3239099210182713
Instituição:
Faculdade de Medicina da USP
Departamento de Gastroenterologia
Av. Dr. Enéas Carvalho de Aguiar, 255
ICHC - 9º andar - sala 9159
CEP 05403-000 São Paulo - SP
Tel: (11) 2661-7830
Fax: (11) 2661-7830