Farmacogenética em doenças infecciosas e não infecciosas

Linhas de pesquisa com interface com a REFARGEN

Publicações selecionadas

1. Teixeira RL, Miranda AB, Pacheco AG, Lopes MQ, Fonseca-Costa J, Rabahi MF, Melo HM, Kritski AL, Mello FC, Suffys PN, Santos AR. Genetic profile of the arylamine N-acetyltransferase 2 coding gene among individuals from two different regions of Brazil. Mutat Res. 2007 Nov 1;624(1-2):31-40. Epub 2007 Apr 19. PubMed PMID: 17509624.
2. Possuelo LG, Castelan JA, de Brito TC, Ribeiro AW, Cafrune PI, Picon PD, Santos AR, Teixeira RL, Gregianini TS, Hutz MH, Rossetti ML, Zaha A. Association of slow N-acetyltransferase 2 profile and anti-TB drug-induced hepatotoxicity in patients from Southern Brazil. Eur J Clin Pharmacol. 2008 Jul;64(7):673-81. doi:10.1007/s00228-008-0484-8. Epub 2008 Apr 18. PubMed PMID: 18421452.
3. Teixeira RL, Silva FP Jr, Silveira AR, Cabello PH, Mendonça-Lima L, Rabahi MF, Kritski AL, Mello FC, Suffys PN, de Miranda AB, Santos AR. Sequence analysis of NAT2 gene in Brazilians: identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure. Mutat Res. 2010 Jan 5;683(1-2):43-9. doi:10.1016/j.mrfmmm.2009.10.009. Epub . PubMed PMID: 19909761.
4. Teixeira RL, Morato RG, Cabello PH, Muniz LM, Moreira Ada S, Kritski AL, Mello FC, Suffys PN, Miranda AB, Santos AR. Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients. Mem Inst Oswaldo Cruz. 2011 Sep;106(6):716-24. PubMed PMID: 22012226.
5. Cardoso CC, Pereira AC, Brito-de-Souza VN, Duraes SM, Ribeiro-Alves M, Nery JA, Francio ÂS, Vanderborght PR, Parelli FP, Alter A, Salgado JL, Sampaio EP, Santos AR, Oliveira ML, Sarno EN, Schurr E, Mira MT, Pacheco AG, Moraes MO. TNF-308G> A single nucleotide polymorphism is associated with leprosy among Brazilians: a genetic epidemiology assessment, meta-analysis, and functional study. J Infect Dis. 2011 Oct 15;204(8):1256-63. doi: 10.1093/infdis/jir521. PubMed PMID: 21917899.
6. Coelho MB, Costa ER, Vasconcellos SE, Linck N, Ramos RM, Amorim HL, Suffys PN, Santos AR, Silva PE, Ramos DF, Silva MS, Rossetti ML. Sequence and structural characterization of tbnat gene in isoniazid-resistant Mycobacterium tuberculosis: identification of new mutations. Mutat Res. 2011 Jul 1;712(1-2):33-9. doi: 10.1016/j.mrfmmm.2011.03.017. Epub 2011 Apr 14. PubMed PMID: 21514309.