Centro de Investigação Translacional em Oncologia (CTO)

Linhas de pesquisa com interface com a REFARGEN

• Oncologia Molecular
• Inovação Terapêutica e Diagnóstica
• Pesquisa Clínica

Publicações selecionadas

1. Fernández-Medina RD, Ribeiro JM, Carareto CM, Velasque L, Struchiner CJ.Losing identity: structural diversity of transposable elements belonging to different classes in the genome of Anopheles gambiae. BMC Genomics. 2012 Jun 22;13:272. doi: 10.1186/1471-2164-13-272. PubMed PMID: 22726298; PubMed Central PMCID: PMC3442997
2. Gimenez M, Marie SK, Oba-Shinjo SM, Uno M, da Silva R, Laure HJ, Izumi C, Otake A, Chammas R, Rosa JC. Quantitative proteomic analysis and functional studies reveal that nucleophosmin is involved in cell death in glioblastoma cell line transfected with siRNA. Proteomics. 2012 Aug;12(17):2632-40. doi: 10.1002/pmic.201200034. PMID: 22745010
3. Otake AH, Mattar AL, Freitas HC, Machado CM, Nonogaki S, Fujihara CK, Zatz R, Chammas R. Inhibition of angiotensin II receptor 1 limits tumor-associated angiogenesis and attenuates growth of murine melanoma. Cancer Chemother Pharmacol. 2010 May;66(1):79-87. doi: 10.1007/s00280-009-1136-0. PMID: 19771429
4. Mangone FR, Bobrovnitchaia IG, Salaorni S, Manuli E, Nagai MA. PIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients. Clinics (Sao Paulo). 2012 Nov;67(11):1285-90. PMID: 23184205
5. Nagai MA, Brentani MM. Gene expression profiles in breast cancer to identify estrogen receptor target genes. Mini Rev Med Chem. 2008 May;8(5):448-54. Review. PMID: 18473934
6. Francisco G, Menezes PR, Eluf-Neto J, Chammas R. Arg72Pro TP53 polymorphism and cancer susceptibility: a comprehensive meta-analysis of 302 case-control studies. Int J Cancer. 2011 Aug 15;129(4):920-30. doi: 10.1002/ijc.25710. Epub 2010 Dec 2. PMID: 20886596
7. Onuchic AC, Machado CM, Saito RF, Rios FJ, Jancar S, Chammas R. Expression of PAFR as part of a prosurvival response to chemotherapy: a novel target for combination therapy in melanoma. Mediators Inflamm. 2012;2012:175408. doi: 10.1155/2012/175408. Epub 2012 Apr 18. PMID: 22570511
8. Fratini P, Strauss BE. Serial bone marrow transplantation reveals in vivo expression of the pCLPG retroviral vector. Virol J. 2010 Jan 22;7:16. doi: 10.1186/1743-422X-7-16. PMID: 20096105
9. Merkel CA, da Silva Soares RB, de Carvalho AC, Zanatta DB, Bajgelman MC, Fratini P, Costanzi-Strauss E, Strauss BE. Activation of endogenous p53 by combined p19Arf gene transfer and nutlin-3 drug treatment modalities in the murine cell lines B16 and C6. Source. BMC Cancer. 2010 Jun 22;10:316. doi: 10.1186/1471-2407-10-316. PMID: 20569441
10. Villa LL, Costa RL, Petta CA, Andrade RP, Ault KA, Giuliano AR, Wheeler CM, Koutsky LA, Malm C, Lehtinen M, Skjeldestad FE, Olsson SE, Steinwall M, Brown DR, Kurman RJ, Ronnett BM, Stoler MH, Ferenczy A, Harper DM, Tamms GM, Yu J, Lupinacci L, Railkar R, Taddeo FJ, Jansen KU, Esser MT, Sings HL, Saah AJ, Barr E.Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial. Lancet Oncol. 2005 May;6(5):271-8. PMID: 15863374