Laboratório de Diversidade Genética Humana

Linhas de pesquisa com interface com a REFARGEN

• Epidemiologia genética de doenças complexas na América Latina
• Diversidade genômica humana na América Latina: implicações biomédicas e inferências evolutivas
• Ferramentas bioinformáticas para o estudo da diversidade genética

Publicações selecionadas

1. Dorado P, Beltrán LJ, Machín E, Peñas-Lledó EM, Terán E, Llerena A; CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics RIBEF (Tarazona-Santos E is part of this Consortium). Losartan hydroxylation phenotype in an Ecuadorian population: influence of CYP2C9 genetic polymorphism, habits and gender. Pharmacogenomics. 2012. 13(15):1711-7.
2. Pereira L, Zamudio R, Soares-Souza G, Herrera P, Cabrera L, Hooper CC, Cok J, Combe JM, Vargas G, Prado WA, Schneider S, Kehdy F, Rodrigues MR, Chanock SJ, Berg DE, Gilman RH, Tarazona-Santos E. Socioeconomic and nutritional factors account for the association of gastric cancer with Amerindian ancestry in a Latin American admixed population. PLoS One. 2012;7(8):e41200.
3. Rodrigues MR, Magalhães WC, Machado M, Tarazona-Santos E. A graph-based approach for designing extensible pipelines. BMC Bioinformatics. 2012. 13:163.
4. Rodeiro I, Remírez-Figueredo D, García-Mesa M, Dorado P, LLerena A; CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics and Pharmacogenomics RIBEF (Tarazona-Santos E is part of this Consortium). Pharmacogenetics in Latin American populations: regulatory aspects, application to herbal medicine, cardiovascular and psychiatric disorders. Drug Metabol Drug Interact. 2012. 27(1):57-60.
5. Magalhães WC, Rodrigues MR, Silva D, Soares-Souza G, Iannini ML, Cerqueira GC,Faria-Campos AC, Tarazona-Santos E. DIVERGENOME: a bioinformatics platform to assist population genetics and genetic epidemiology studies. Genet Epidemiol. 2012. 36(4):360-7.
6. da Silva MC, Zuccherato LW, Lucena FC, Soares-Souza GB, Vieira ZM, Pena SD, Martins ML, Tarazona-Santos E. Extensive admixture in Brazilian sickle cell patients: implications for the mapping of genetic modifiers. Blood. 2011. 118(16):4493-5.
7. Breunis WB, Tarazona-Santos E, Chen R, Kiley M, Rosenberg SA, Chanock SJ. Influence of cytotoxic T lymphocyte-associated antigen 4 (CTLA4) common polymorphisms on outcome in treatment of melanoma patients with CTLA-4 blockade. J Immunother. 2008. 31(6):586-90.
8. Fuselli S, Gilman RH, Chanock SJ, Bonatto SL, De Stefano G, Evans CA, Labuda D, Luiselli D, Salzano FM, Soto G, Vallejo G, Sajantila A, Pettener D, Tarazona-Santos E. Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity. Pharmacogenomics J. 2007. 7(2):144-52.