Aspectos Moleculares na Caracterização e Tratamento de Doenças Multifatoriais

Linhas de pesquisa com interface com a REFARGEN:

• Farmacogenômica
• Variabilidade genômica e doenças multifatoriais

Publicações selecionadas

1. Smiderle L, Mattevi VS, Giovenardi M, Wender MC, Hutz MH, Almeida S. Are polymorphisms in oestrogen receptors genes associated with lipid levels in response to hormone therapy? Gynecol Endocrinol. 2012 Aug;28(8):644-8. doi:10.3109/09513590.2011.650767. Epub 2012 Feb 10. PubMed PMID: 22324545.
2. Lima LO, Almeida S, Hutz MH, Fiegenbaum M. PPARA, RXRA, NR1I2 and NR1I3 gene polymorphisms and lipid and lipoprotein levels in a Southern Brazilian population. Mol Biol Rep. 2013 Feb;40(2):1241-7. doi: 10.1007/s11033-012-2166-y. Epub 2012 Oct 19. PubMed PMID: 23079705.
3. Turatti L, Sprinz E, Lazzaretti RK, Kuhmmer R, Agnes G, Silveira JM, Basso RP, Pinheiro CA, Silveira MF, de Almeida S, Ribeiro JP, Mattevi VS. Short communication: UGT1A1* 28 variant allele is a predictor of severe hyperbilirubinemia in HIV-infected patients on HAART in southern Brazil. AIDS Res Hum Retroviruses. 2012 Sep;28(9):1015-8. doi: 10.1089/AID.2011.0261. Epub 2012.May 3. PubMed PMID: 22050734.
4. Gasparotto AS, Sprinz E, Lazzaretti RK, Kuhmmer R, Silveira JM, Basso RP, Pinheiro CA, Silveira MF, Ribeiro JP, Mattevi VS. Genetic polymorphisms in estrogen receptors and sexual dimorphism in fat redistribution in HIV-infected patients on HAART. AIDS. 2012 Jan 2;26(1):19-26. doi: 10.1097/QAD.0b013e32834db3ac. PubMed PMID: 22011627.
5. Galvão AC, Krüger RC, Campagnolo PD, Mattevi VS, Vitolo MR, Almeida S. Association of MAOA and COMT gene polymorphisms with palatable food intake in children. J Nutr Biochem. 2012 Mar;23(3):272-7. doi: 10.1016/j.jnutbio.2010.12.004. Epub 2011 May 6. PubMed PMID: 21530215.
6. Smiderle L, Galvão AC, Fontana C, Wender MC, Agnes G, Giovenardi M, Hutz MH, Almeida S. Evaluation of UGT1A1 and SULT1A1 polymorphisms with lipid levels in women with different hormonal status. Gynecol Endocrinol. 2011 Jan;27(1):20-6. doi: 10.3109/09513590.2010.493248. Epub 2010 Jun 9. PubMed PMID: 20528568.
7. Trinca JR, Sprinz E, Lazzaretti RK, Hutz MH, Kuhmmer R, de Almeida S, Tibola A, Meirelles GB, Arena-de-Souza RC, Mattevi VS. SNPs in the APM1 gene promoter are associated with adiponectin levels in HIV-infected individuals receiving HAART. J Acquir Immune Defic Syndr. 2010 Nov;55(3):299-305. PubMed PMID: 20964254.