Variabilidade Normal e Patológica do Genoma Humano

Linhas de pesquisa com interface com a REFARGEN

  • Suscetibilidade genética e farmacogenômica em doenças neuropsiquiátricas
  • Suscetibilidade genética e farmacogenômica em doenças negligenciadas
  • Suscetibilidade genética e farmacogenômica em doenças cardiovasculares

Publicações selecionadas

  1. Sortica VA, Cunha MG, Ohnishi MD, Souza JM, Ribeiro-Dos-Santos AK, Santos NP, Callegari-Jacques SM, Santos SE, Hutz MH. IL1B, IL4R, IL12RB1 and TNF gene polymorphisms are associated with Plasmodium vivax malaria in Brazil. Malar J. 2012 Dec 7;11:409. doi: 10.1186/1475-2875-11-409. PubMed PMID: 23217179; PubMed Central PMCID: PMC3537609.
  2. Schumacher-Schuh AF, Francisconi C, Altmann V, Monte TL, Callegari-Jacques SM, Rieder CR, Hutz MH. Polymorphisms in the dopamine transporter gene are associated with visual hallucinations and levodopa equivalent dose in Brazilians with Parkinson's disease. Int J Neuropsychopharmacol. 2013 Jan 30:1-8. [Epub ahead of print] PubMed PMID: 23363854.
  3. Rieck M, Schumacher-Schuh AF, Altmann V, Francisconi CL, Fagundes PT, Monte TL, Callegari-Jacques SM, Rieder CR, Hutz MH. DRD2 haplotype is associated with dyskinesia induced by levodopa therapy in Parkinson's disease patients. Pharmacogenomics. 2012 Nov;13(15):1701-10. doi: 10.2217/pgs.12.149. PubMed PMID: 23171335.
  4. Friedrich DC, Santos SE, Ribeiro-dos-Santos ÂK, Hutz MH. Several different lactase persistence associated alleles and high diversity of the lactase gene in the admixed Brazilian population. PLoS One. 2012;7(9):e46520. doi: 10.1371/journal.pone.0046520. Epub 2012 Sep 28. PubMed PMID: 23029545; PubMed Central PMCID: PMC3460917.
  5. Bruxel EM, Salatino-Oliveira A, Genro JP, Zeni CP, Polanczyk GV, Chazan R, Rohde LA, Hutz MH. Association of a carboxylesterase 1 polymorphism with appetite reduction in children and adolescents with attention-deficit/hyperactivity disorder treated with methylphenidate. Pharmacogenomics J. 2012 Jun 12. doi: 10.1038/tpj.2012.25. [Epub ahead of print] PubMed PMID: 22688218.
  6. Sortica VA, Fiegenbaum M, Lima LO, Van der Sand CR, Van der Sand LC, Ferreira ME, Pires RC, Hutz MH. SLCO1B1 gene variability influences lipid-lowering efficacy on simvastatin therapy in Southern Brazilians. Clin Chem Lab Med. 2012 Mar;50(3):441-8. doi: 10.1515/cclm.2011.804. PubMed PMID: 22505549.
  7. Sortica Vde A, Ojopi EB, Genro JP, Callegari-Jacques S, Ribeiro-Dos-Santos A, de Moraes MO, Romano-Silva MA, Pena SD, Suarez-Kurtz G, Hutz MH. Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians. Basic Clin Pharmacol Toxicol. 2012 May;110(5):460-8. doi: 10.1111/j.1742-7843.2011.00838.x. Epub 2011 Dec 29. PubMed PMID: 22136368.
  8. Tovo-Rodrigues L, Rohde LA, Roman T, Schmitz M, Polanczyk G, Zeni C, Marques FZ, Contini V, Grevet EH, Belmonte-de-Abreu P, Bau CH, Hutz MH. Is there a role for rare variants in DRD4 gene in the susceptibility for ADHD? Searching for an effect of allelic heterogeneity. Mol Psychiatry. 2012 May;17(5):520-6. doi: 10.1038/mp.2011.12. Epub 2011 Mar 15. PubMed PMID: 21403674.
  9. Botton MR, Bandinelli E, Rohde LE, Amon LC, Hutz MH. Influence of genetic, biological and pharmacological factors on warfarin dose in a Southern Brazilian population of European ancestry. Br J Clin Pharmacol. 2011 Sep;72(3):442-50. doi: 10.1111/j.1365-2125.2011.03942.x. PubMed PMID: 21320153; PubMed Central PMCID: PMC3175513.
  10. Genro JP, Kieling C, Rohde LA, Hutz MH. Attention-deficit/hyperactivity disorder and the dopaminergic hypotheses. Expert Rev Neurother. 2010 Apr;10(4):587-601. doi: 10.1586/ern.10.17. Review. PubMed PMID: 20367210.

Líder(es) do grupo:

Mara Helena Hutz
E-mail: mara.hutz@ufrgs.br
Lattes: 9135538820816061


Instituição:

Universidade Federal do Rio Grande do Sul - UFRGS

Departamento de Genética

Departamento de Genética, UFRGS
Caixa Postal 15053
91501-970 Porto Alegre-RS

Tel: (51) 3308-6720
Fax: (51) 3308-7311







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