Enantiosseletividade: Análise, Metabolismo e Disposição Cinética de Fármacos

Linhas de pesquisa com interface com a REFARGEN:

• Influência de doenças sobre a disposição cinética de fármacos cardiovasculares
• Pesquisa Clínica
• Farmacologia Clínica com destaque para estudos de interação medicamentosa
• Toxicogenética
• Desenvolvimento de medicamentos baseados na biodiversidade brasileira

Publicações selecionadas

1. Albendazole-praziquantel interaction in healthy volunteers: kinetic disposition, metabolism and enantioselectivity. Lima RM, Ferreira MA, de Jesus Ponte Carvalho TM, Dumêt Fernandes BJ, Takayanagui OM, Garcia HH, Coelho EB, Lanchote VL.Br J Clin Pharmacol. 2011 Apr;71(4):528-35. doi: 10.1111/j.1365-2125.2010.03874.x.
2. Omeprazole preferentially inhibits the metabolism of (+)-(S)-citalopram in healthy volunteers. Rocha A, Coelho EB, Sampaio SA, Lanchote VL. Br J Clin Pharmacol. 2010 Jul;70(1):43-51. doi: 10.1111/j.1365-2125.2010.03649.x.
3. Influence of glomerular filtration rate on the pharmacokinetics of Cyclophosphamide enantiomers in patients with lupus nephritis. de Miranda Silva C, Fernandes BJ, Donadi EA, Silva LM, Coelho EB, Dantas M, Marques MP, Lanchote VL. J Clin Pharmacol. 2009 Aug;49(8):965-72. oi:10.1177/0091270009337938. Epub 2009 Jun 22.
4. Influence of quinidine, cimetidine, and ketoconazole on the enantioselective pharmacokinetics and metabolism of metoprolol in rats. Boralli VB, Coelho EB, Lanchote VL. Chirality. 2009 Nov;21(10):886-93. doi: 10.1002/chir.20682.
5. Enantioselectivity in the pharmacokinetic interaction between fluvastatin and lercanidipine in healthy volunteers. Boralli VB, Coelho EB, Sampaio SA, Marques MP, Lanchote VL. J Clin Pharmacol. 2009 Feb;49(2):205-11. doi: 10.1177/0091270008327536. Epub 2008 Nov 25.
6. Investigation of the in vivo activity of CYP3A in Brazilian volunteers: comparison of midazolam and omeprazole as drug markers. Rocha A, Coelho EB, Moussa SA, Lanchote VL.Eur J Clin Pharmacol. 2008 Sep;64(9):901-6. doi: 10.1007/s00228-008-0510-x. Epub 2008 Jun 26.
7. The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. Pretorius MM, Gainer JV, Van Guilder GP, Coelho EB, Luther JM, Fong P, Rosenbaum DD, Malave HA, Yu C, Ritchie MD, Vaughan DE, Brown NJ.
8. Influence of chronic renal failure on stereoselective metoprolol metabolism in hypertensive patients.Cerqueira PM, Coelho EB, Geleilete TJ, Goldman GH, Lanchote VL.J Clin Pharmacol. 2005 Dec;45(12):1422-33.
9. Susceptible and protective eNOS haplotypes in hypertensive black and white subjects.Sandrim VC, Coelho EB, Nobre F, Arado GM, Lanchote VL, Tanus-Santos JE.Atherosclerosis. 2006 Jun;186(2):428-32. Epub 2005 Sep 15.
10. Dynamic and kinetic disposition of nisoldipine enantiomers in hypertensive patients presenting with type-2 diabetes mellitus.Marques MP, Coelho EB, Dos Santos NA, Geleilete TJ, Lanchote VL.Eur J Clin Pharmacol. 2002 Dec;58(9):607-14. Epub 2002 Nov 16.